Neptune and Pluto have been in rough sextile relationship(particularly by sign) for almost 100 years now(1930's to 2030's). This unique configuration has a great impact on the natal personal planets, especially Moon and Ascendant, for decades at a time. Whether those decades are generally favorable or not depends on the sign positions of your Moon and Ascendant.

Why your Moon and Ascendant? Because these are the fastest and therefore the most personal parts of your chart. I would emphasize your Moon sign in particular, because of its special relationship to Neptune and Pluto. All three are water sign rulers and concerned with family or personal(emotional) issues.

Most importantly, however, is my own personal observation over many years of how these two outermost planets(Neptune and Pluto) have affected my social and personal life. I have noted that the most positive and eventful periods of my life in terms of friends, social, and family life have been when transiting Neptune and Pluto are both in the same gender as my natal Moon and also when NOT in the same gender as my natal Ascendant.

So if I have the Moon in Leo(masculine) my best decades are when both Neptune and Pluto are in fire or air(also masculine). This will be doubly so if my Ascendant is feminine(earth or water). You do not want heavy or negative planets like Neptune and Pluto weighing on your Ascendant. Gender is the first rule in synastry. An immediate blending occurs when planets are in the same gender (masculine is fire or air and feminine is earth or water). The element or sign is more specific, and the closeness by degree indicates the intensity.

I look back fondly to the 1970's and early 1980's when both Neptune(in Sag) and Pluto(in Libra) were complementing my Moon and not sensitizing my Ascendant. It was a very sociable and eventful period, especially when Uranus (in Libra) joined in the mix, and one of the only problems I noted when looking back is a tendency to be sloppy or careless where diet and hygiene are concerned (enjoy now, pay later). The decades before and after were quite stark by comparison, followed by another favorable but quieter period in the 2000's when Neptune(in Aquarius) and Pluto(in Sag) again complemented my Moon and stayed away from my Ascendant.

Of course, there are bright and dark periods within every Neptune sextile Pluto generational period and it would be to complicated for me to delineate. There are also shorter times when Neptune and Pluto are in semi-sextile or square by sign, rather than sextile, giving mixed results. Here are the general time periods of the Neptune sextile Pluto sign periods over the last 100 years. An ephemeris or computer program is neede for the specific days.